Wehave previously reported high circulating levels of the immunosuppressivecytokines IL-10 and TGF-β in mice during late sepsis [18] and MDSCs from these mice produced copiousamounts of IL-10 and TGF-β upon ex vivo stimulation withbacterial Lipopolysaccharide (LPS). The gene discussed is TGFB1; the disease is Sepsis.