ANKRD17 and neoplasm: ANKRD17-overexpressing cells and tumor samples revealed significantly higher expression of yes-associated protein 1 (Yap1), indicative of a dysregulated HIPPO signaling pathway (Figure 3A), and notably elevated AKT phosphorylation at Ser473, an indicator of a dysregulated PTEN signaling pathway (Figures 3B and 3C, respectively).