For example, in a study from southern Sweden, where patients with early RA (<12 months symptom duration) were followed according to a structured program, and RRP was defined as an increase of >5 points/year over 5 years in the modified Sharp-van der Heijde score, RF and ACPA were both associated with a markedly increased risk of RRP (Table 1) [43]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.