DKC1 and cancer: To thoroughly understand the role for telomerase and telomere maintenance in UCEC development and progression, we performed comprehensive analyses of two telomerase cofactors DKC1 in UCEC tumors with the following findings: (1) The genomic alterations and dysregulated expression of DKC1 are widespread in UCEC tumors; (2) Higher DKC1 expression at either mRNA or protein level is associated with aggressive UCEC and significantly shorter patient survival; (3) DKC1-high tumors are characterized by frequent UCEC-driver alterations, aggressive phenotypes and impaired anti-cancer immunity.