APP and Cognitive impairment: Aluminum (Al) can penetrate the blood–brain barrier, gradually accumulate in brain tissue, decrease ACh levels in zebrafish brains, disrupt neuronal structure, reduce the expression of brain‐derived neurotrophic factor and mammalian rapamycin target protein genes, increase the expression of amyloid precursor protein (APP) and Tau protein, leading to cognitive impairments (Gao et al. 2022; Niu 2018).