The advent of gene-editing technologies has enabled the systemic or conditional knockout of genes such as PITX2c (Kirchhof et al., 2011), Mkk4 (Davies et al., 2014), and LKB1 (Ozcan et al., 2015), facilitating the development of murine models that recapitulate key features of AF. This evidence concerns the gene STK11 and atrial fibrillation.