We decided to use the DSS colitis model to avoid confounding effects of immunodeficiency on beta‐amyloid pathology (SCID/RAG2‐/‐) and because IL‐10 crossed with beta‐amyloid overexpressing mice have reduced deposition,21 showing that IL‐10 plays a role in beta‐amyloid pathology. Here, RAG2 is linked to immunodeficiency disease.