Via upregulation of CD11b+CD103-dendritic cell activities in the mature LNs, FimH induces Th1 and Th17 differentiation, thus breaking the immune balance of the host, which aggravates the disease progression of E. coli infectious colitis.278 Notably, during infection, IL-17 may promote IL-22 secretion and play a protective role in E. coli infectious colitis.279. This evidence concerns the gene ITGAE and infectious colitis.