SNX5 and Parkinson disease: Of the 28 secondary hits, 12 protected specifically against αSyn-induced toxicity (T-tests), and 4 of them (esiRNAs against SNX5, DYNLRB1, CEFB, and GHR) remained significant after correction for multiple testing (Fig. 1e, f). The esiRNA with the lowest P value targeted SNX5. Therefore, we decided to further elucidate the role of SNX5 in our PD cell model.