The 22 common hub genes, except DDX3Y, SEP15, and EFEMP2, from both groups were also common in the hub of hub genes, with the mean degree of the common hub of hub genes being 4.8 (range, 2–10) in the normal and 4.27 (range, 2–12) in the tumor. The gene discussed is EFEMP2; the disease is neoplasm.