Nonetheless, the results presented in this manuscript build on our previous report that healthy NOX4OE ECFCs show enhanced angiogenic function and signalling in vitro and promote in vivo neovascularisation [10] to support selective manipulation of NOX4 and/or its downstream signalling targets as an innovative approach towards improving endogenous vasoreparative capacity in diabetes and basis for future translational studies. Here, NOX4 is linked to diabetes mellitus.