NOX4 and gestational diabetes: It is interesting to note that NOX4OE did not impact CB-ECFC migration and tubulogenesis with short-term high glucose exposure alone (Fig. 2), suggesting that exogenous or endogenous stimulation may be required for cell priming to support NOX4-induced enhancement of angiogenic capacity, as observed in response to both in vitro PMA treatment and exposure to in vivo stress linked with gestational diabetes (Figs. 2 and 5).