ANKHD1 and autosomal dominant polycystic kidney disease: ANKHD1 is a critical regulator of cell proliferation in cancer, yet remains unexplored in ADPKD. ANKHD1’s potential significance in ADPKD is its known role as a driver of cancer and a significant regulator of pathways involved in ADPKD, such as JAK/STAT and YAP/TAZ.