ANKHD1 and autosomal dominant polycystic kidney disease: While this study establishes ANKHD1 as a key regulator of proliferation in ADPKD, further research is needed to validate its role in human patient samples, explore its interactions with other cystogenic pathways, and assess feasibility of targeting ANKHD1 therapeutically using siRNA based therapies and/or going downstream of ANKHD1.