Ankyrin repeat and Single KH Domain 1 (ANKHD1) is an RBP that binds various RNA species [35, 36] and has been identified as a regulator of signalling pathways relevant to ADPKD, including the Hippo [37], JAK/STAT [38] and CDK pathways [39]. Here, SOAT1 is linked to autosomal dominant polycystic kidney disease.