However, a larger clinical trial encompassing 11,017 participants (mean age 48 years, ranging from 18-95 years, and 58% female), receiving vitamin D supplementation for 12 months, reported decreases in serum TSH, anti-TPO, anti-TG and TG levels over time, and increases in serum FT3 and FT4, leading to reduction in hypothyroidism and thyroid autoimmune disorder [34]. The gene discussed is TPO; the disease is hypothyroidism.