TLR4 and colorectal carcinoma: Several signaling pathways play the crucial role in the regulation of CRC, including the pathways Wnt/β-Catenin (β-Catenin) [5], Phosphatidylinositol 3-kinase (PI3K) [6], transforming growth factor (TGF-β), Epidermal growth factor receptor (EGFR) (TGF-α) [6], Notch (HES1, PTEN), Hedgehog (SHH) (Bcl2, Gli2) [7], and genes such as interleukin 6 (IL-6), Toll-like receptor 4 (TLR4) [8], and carcinoembryonic antigen (CEA) [9].