However, numerous studies have confirmed that CSNP is a unique compound, which shows different effects on cancer signaling pathways after conjugated with various agents such as programmed death ligand 1, ribonucleotide reductase regulatory subunit M2, insulin like growth factor 1 receptor, folic acid, glycyrrhetinic acid, and herceptin [48, 49]. Here, RRM2 is linked to cancer.