Thus, in order to elucidate the associations between AKI and subsequent HF, we investigated the combined use of angiopoietins (Angpt-1, Angpt-2) and their soluble Tie-2 receptor (sTie2), the vascular endothelial growth factor family (VEGF A, C, D) and their main receptor (VEGFR1), placental growth factor (PlGF), and basic fibroblast growth factor (bFGF) to subgroup individuals into phenotypes, and to determine the association of these phenotypes with patient outcomes. This evidence concerns the gene FGF2 and hydrops fetalis.