In Rag1−/− animals reconstituted with B16 melanoma, WT CD45.2+ Treg cells and CD45.1+ naive CD4+ T cells, we found no difference in tumor growth between those in which reconstitution was followed by anti-CD153 treatment and those who received the isotype control (Fig. 3h). The gene discussed is TNFSF8; the disease is neoplasm.