Furthermore, native LIGHT produced by neutrophils, NK, and T cells and recombinant LIGHT along with LTα1β2 secreted by recruited B cells (LTi, lymphoid tissue inducer cells) would together activate stromal cells of the tumor microenvironment (TME) through LTβR (LTo, lymphoid tissue organizing cells) to release chemokines driving endothelial activation and the upregulation of adhesion molecules that in turn would facilitate transmigration of immune cells from the blood vessels to the tumor site. This evidence concerns the gene LTBR and neoplasm.