Similarly, SNCA, STX1B, PRS533, HSD3B7, LRRK2, and GPNMB all increase the OR for PD and a) affect autophagosome-lysosome fusion through effects on another factor/stage of the process (SNCA, STX1B, HSD3B7, PRSS53, and LRRK2), or directly affect the lysosome (GPNMB). The gene discussed is LRRK2; the disease is Parkinson disease.