Interestingly, we identified ten genes (ELOVL7, HSD3B7, PLEKHM1, PRSS53, SNCA, STX1B, STX4, ZSWIM7, LINC02210, and RP11-1072 A3.3) that were causally related with PD but associated sceQTLs that linked to both protection and risk for PD in a tissue-specific manner. This evidence concerns the gene PRSS53 and Parkinson disease.