For instance, the allele-specific variants surrounding the PLEKHM1 gene, rs8070723 and rs56168933, modulate tissue-specific expression of PLEKHM1. Notably, rs8070723 is linked to the H1 haplotype of the 17q.21.31 locus, previously implicated in PD risk [49]. This evidence concerns the gene PLEKHM1 and Parkinson disease.