However, ten genes ELOVL7, HSD3B7, PLEKHM1, PRSS53, SNCA, STX1B, STX4, ZSWIM7, LINC02210, and RP11-1072 A3.3 were associated with increased or decreased PD risk (i.e. they had opposite effects) in a tissue specific manner (Fig. 1C; Supplementary Table 12). Here, PRSS53 is linked to Parkinson disease.