Ten genes (ELOVL7, HSD3B7, PLEKHM1, PRSS53, SNCA, STX1B, STX4, ZSWIM7, LINC02210, and RP11-1072 A3.3) showed causal associations with tissue-specific expression patterns driving risk or protection for PD. The gene discussed is PRSS53; the disease is Parkinson disease.