This reduced intronic binding coincided with a >2.5-fold depletion in TDP-43 binding to the ALS-linked cryptic exon splice sites in STMN2 and UNC13A (Extended Data Fig. 4a–c), although we did not detect cryptic exon expression (Extended Data Fig. 4d). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.