For this purpose, we analyzed inhibition of protein translation via cycloheximide (CHX) treatment in HEK293 cells overexpressing USP28 or HG3 cells with CRISPR/Cas9-mediated heterozygous USP28 knockout reproducing USP28 knockout similar to del(11q) CLL (USP28WT/KO, Supplementary Fig. 4). The gene discussed is USP28; the disease is B-cell chronic lymphocytic leukemia.