FBXW7 and B-cell chronic lymphocytic leukemia: In addition, NICD and c-MYC protein levels were significantly downregulated in AZ1 treated cells from CLL patients with and without NOTCH1/FBXW7 mutations (NOTCH1/FBXW7 mut n = 6, NOTCH1 wt n = 12; Supplementary Table 4; Fig. 7B and Supplementary Fig. 14).