USP28 and B-cell chronic lymphocytic leukemia: To investigate the expression of these genes in del(11q) patients, we intersected the 129 RBPJ-bound and USP28-dependent genes with genes significantly differentially expressed in del(11q) patient samples of the CLL patient cohort published by Lütge et al. [39] and found 27 overlapping genes (Fig. 5B and Supplementary Fig. 10).