JUN and B-cell chronic lymphocytic leukemia: To further investigate the impact of del(11q) on USP28 and its function to prevent degradation of proteins, we analyzed protein levels of the previously identified FBXW7 target proteins NICD, Cyclin-E and c-JUN [23] in primary cells of CLL patients (Supplementary Table 1) harboring del(11q) (n = 18) and patients without del(11q) (non-del(11q), n = 18).