MTOR and hepatocellular carcinoma: Analysis showed that TCGA HCC samples with high PTEN levels and low PI3K/AKT/mTOR pathway levels (PTEN+/PI3K−/AKT−/mTOR−) had better survival probability compared to samples with low PTEN and high PI3K/AKT/mTOR pathway levels (PTEN−/PI3K+/AKT+/mTOR+) (p = 0.04) (Fig. 8A).