ELMO2 and aneurysm: Despite the carotid artery dilation, other relevant features of the global knockout phenotype were not reproduced after Tagln-Cre-mediated deletion of Elmo2. In particular, there were no signs of aneurysm formation, disorganized VSMC alignment, or altered endothelial morphology, polarity, and gene expression (Fig. 4d and Supplementary Fig. 8b).