Although BTN3A2 and BTN2A1 are known to interact52, given that BTN3A2 and BTN2A1 were separately identified as risk and protective factors for brain disorders in the present study, further studies are needed to elucidate the underlying mechanisms of how BTN3A2 and BTN2A1 proteins are oppositely involved in brain disorders. Here, BTN2A1 is linked to brain disorder.