The inhibitory effect of Phen on TNF-mediated necroptosis was also evident in another human cancer cell line, an ectopic RIPK3-expressing MDA-MB231 cell line, as well as in murine MC-38 cells and MEFs, expanding this observation to multiple cell types and species (Fig. 2D, E and Fig. S2D). The gene discussed is RIPK3; the disease is cancer.