Notably, no difference in RAMP1 levels was found between the blood monocytes from HNSCC patients and healthy donors, suggesting the presence of localized, tumor-specific neural modulation of leukocytes.126 In mice with melanoma, CGRP+ sensory neurons have been found to inhibit antitumoral immune function via the RAMP1 signal, prompting CD8+ T cells exhaustion within TIME. This evidence concerns the gene CD8A and melanoma.