FFAR2 and cancer: In CRC, the expression of FFAR2 is significantly reduced, and propionate, a short-chain fatty acid, has been shown to play a significant role in reducing cell proliferation and inducing apoptosis.374,380,381,392,393 These findings suggest that SCFAs and their activation of FFAR2 and FFAR3 receptors could support a model that may aid in the study of the progression of certain cancers.