CALCA and neoplasm: The use of FDA-approved anti-migraine drugs to block CGRP can significantly enhance the efficacy of tumor starvation therapy.128 In another study, the enrichment of CGRP-positive nerves was also found to be associated with poor prognosis in oropharyngeal squamous cell carcinoma(OPSCC), suggesting that CGRP antagonists may improve patients’ quality of life after radiotherapy.129 Medullary thyroid cancer (MTC) is a neuroendocrine tumor, it is reported that CGRP is highly expressed in MTC cells, which is linked to poorer disease-free survival.