High-mobility group box 1 secreted by TAMs can promote the proliferation, migration, invasion, and mesenchymal transition of glioma cells.80 Lactate dehydrogenase A (LDHA) modulates the behavior of macrophages by regulating the metabolism and secretory signals of tumor cells, thereby promoting the progression of glioblastoma. The gene discussed is LDHA; the disease is glioblastoma.