Most of the branches originate from the trigeminal nerve.122 CGRP, along with αCGRP isomer, are the main synaptic transmitters in the trigeminal ganglion, utilized by nerves through RAMP1-GPCR interaction signaling.123,124 In oral cancer tissue samples, an increase in αCGRP+ neuron innervation has been found, alongside a plethora of RAMP1+, CGRP receptors, as well as lymphocytes infiltrated in TME.125 This suggests that αCGRP plays a significant role in modulating tumor-associated immunity through the RAMP1 signaling pathway, which can be implicated in both innate and adaptive immunity. Here, CALCA is linked to lip and oral cavity carcinoma.