The activation of CRH neurons in CeA led to the proliferation of sympathetic fibers in the breast cancer TME, promoting tumor growth.59 The reduction of sympathetic nerves in TME and the slowing of tumor growth was achieved by pharmacological or genetic blockade of the CRH neurons in the CeA to the lateral paragigantocellular nucleus (LPGi) circuit. The gene discussed is CRH; the disease is breast carcinoma.