ADRB2 and neoplasm: Following that, β2-AR signaling inhibits glycolysis as well as promotes lipids oxidation, augmenting the immunosuppressive response of MDSCs that is dependent on fatty acid oxidation and carnitine palmitoyltransferase 1A.26,137 Moreover, MDSCs treated with the nonselective β-AR agonist (ISO) exhibit increased expression of ARG1 and PD-L1,138,139 contributing to the suppression of T cell-mediated tumor killing, which can be reversed by the use of a β-AR blocker (propranolol).