SPG10 (MIM; Mendelian Inheritance in Man: 604187) is an autosomal dominant hereditary SPG caused by variants in the kinesin family member 5A gene (KIF5A, MIM: 602821), also known as the kinesin heavy chain gene (KHC), which is located at chromosome 12q13 (refs. 2–4). This evidence concerns the gene KIF5A and hereditary spastic paraplegia.