Therefore, in our final experiments, we examined how CD45-SAP conditioning and HSC transplantation affect the development of age-associated hematological malignancies in the NUP98-HOXD13 (NHD13tg) transgenic mouse model, which predisposes to myelodysplastic syndrome (MDS) and acute leukemia32. Here, NUP98 is linked to hematologic disorder.