MYCN and neuroblastoma: Notably, only a modest reduction in cell viability was observed when targeting MYCN within the MYCN non-amplified SH-SY5Y cell line in the presence of CHK1i or ATRi which may be ascribed to the toxicity of either small molecule inhibitor in the context of dysregulated cellular proliferation in neuroblastoma cell lines (See, Supplementary Fig. 15).