To assess the potential role of core apoptosis factors in cell death resulting from Cas9D10A-induced DNA damage, we screened two p53-WT neuroblastoma cell lines (MYCN-amplified NGP and MYCN non-amplified SH-SY5Y)71 for caspase 3 activation, a hallmark of intrinsic apoptosis72,73. The gene discussed is CASP3; the disease is neuroblastoma.