One of the potential uses of α-synuclein tagged iPSC lines is their use in studying synucleinopathies and other diseases such as lysosomal storage diseases, which can present secondary lysosomal aggregation of α-synuclein (Mazzulli et al., 2011; Winder-Rhodes et al., 2012). This evidence concerns the gene SNCA and lysosomal storage disease.