Based on the human protein atlas and our mouse data, the expression of SULT2B1 in humans and rodents is higher in the small intestines than several other metabolic tissues, including the liver, adipose tissue, and skeletal muscle (Fig. S6B), although the small intestine expression of Sult2b1 was not regulated by HFD feeding (Fig. S6C), suggesting that the intestinal SULT2B1 may play the dominant role in obesity and the related metabolic syndromes. The gene discussed is SULT2B1; the disease is obesity due to melanocortin 4 receptor deficiency.