The authors suggested that patients with hypertension and high sodium levels have an interstitial buffering system in the skin with the following characteristics; it is saturated with sodium and water, has increased activation of transcription factor NFAT5 (nuclear factor of activated T cells 5) and VEGF-C pathways, and has increased lymphatic vessel density in the skin due to lymphangiogenesis. Here, NFAT5 is linked to hypertensive disorder.