As shown in Figure 5(a), the levels of p-MEK, p-ERK1/2, and c-myc were reduced by re-expressing Lnc21q22.11 in GC cells, while no obvious difference was observed in p-P38 or p-JNK, indicating that Lnc21q22.11 suppressed MEK/ERK signaling pathway. The gene discussed is MAPK3; the disease is gastric cancer.