LGI1 and focal epilepsy: Monoallelic pathogenic variants in LGI1, a secreted neuronal protein, cause autosomal dominant epilepsy with auditory features [ADEAF, previously known as autosomal dominant lateral temporal lobe epilepsy (ADLTE), OMIM: #600512)].1,2 ADEAF is characterized by focal epilepsy of childhood/adolescence with auditory auras.