LGI1 and epilepsy: This is akin to mouse genetic evidence, in which Lgi1−/−, Adam22−/− and Adam23−/− mice commonly show severe, infantile lethal epilepsy.4,8-10 Together with phenotypic analyses of mouse models for LGI1- and ADAM22-variants, this study establishes the disease spectrum caused by the loss-of-function of the LGI1–ADAM22/23 pathway (Supplementary material, ‘Discussion’ section).