The immune rejection and immune-desert phenotypes are considered to indicate noninflammatory tumors, primarily tumors that lack immune cell invasion in the parenchyma and stroma, rarely express PD-L1, are located at the opposite end of the tumor immune continuum, and histologically lack immune invasion and antigen presentation (low MHC class I), while exhibiting high tumor cell proliferation. This evidence concerns the gene CD274 and neoplasm.