No difference in OD was observed between the study and comparison group, which is consistent with preclinical [37,38] and pharmacokinetic modeling studies [39,40], suggesting that use of CYP2D6 inhibitors alone with oxycodone is not associated with increased oxycodone and oxymorphone concentration, a major underlying cause of OD. The gene discussed is CYP2D6; the disease is osteochondritis dissecans.