TP53 and cancer: From the SNVs related to cancer, it was shown that ESCA sublines and patient’s primary tumor share some driven genes, including TP53 (NM_001126115:exon1:c.G42 A:p.W14X),TRRAP(NM_003496:exon59:c.C9032 T:p.A3011 V),CCNB1IP1(NM_182849:exon5:c.C550 T:p.R184X),NUTM1(NM_001284293:exon7:c.2342_2352 del:p.G781fs)andARHGAP35(NM_004491:exon1:c.1468_1470 del:p.490_490 del) (Fig. 6b).