To confirm the DAPK1 function in HTN, negative control and DAPK1 knocked-down (KD), AAV was constructed and injected into WKY and SHR through the tail vein to construct a control group (sh-Control) and DAPK1 KD (sh-DAPK1) WKY and SHR models. The gene discussed is DAPK1; the disease is hypertensive disorder.