RNA sequencing results demonstrated diverse DETs, including MAPK8 [42], Foxo3 [43], Caspase3 [44], and enriched pathways such as the TNF [45], PI3K-Akt [46], and Jak-STAT pathways [47], all of which play a vital role in HTN-induced vascular dysfunction. Here, MAPK8 is linked to hypertensive disorder.