ROC curve analysis demonstrated that the model effectively predicts patient outcomes, with significantly higher EFS and OS rates observed in children with elevated CADPS expression compared to those with lower levels.Although PCR-based assays or RNA panels could theoretically enable quantification of CADPS in clinical settings, routine implementation requires overcoming two major challenges: (1) establishing robust prognostic thresholds and (2) validating stable reference genes specific to fusion-negative ALL patients through systematic experimental studies. Here, CADPS is linked to acute lymphoblastic leukemia.