This reaction iscatalyzed by cholinesterases (ChEs): acetylcholinesterase (AChE) andbutyrylcholinesterase (BChE). In the healthyadult brain, the enzymatic activity of AChE is dominant (i.e., thisenzyme hydrolyzes approximately 80% of ACh), while BChE plays a supportingrole and hydrolyzes approximately 20% of the neurotransmitter. The current arsenal of drugs for the treatmentof AD contains 6 drugs: donanemab, lecanemab, memantine, donepezil,rivastigmine and galantamine. This evidence concerns the gene ACHE and Alzheimer disease.