ACHE and Alzheimer disease: In late stages of AD, the supporting role ofBChE in ACh hydrolysischanges to a leading role.−, ,  Because of this phenomena and the procognitive effectsof selective BChE inhibitors in vivo, without peripheral (parasympathomimetic)adverse effects,−, , , , , , , ,  which are typical for AChE inhibitors and limit their use,−,  selective BChE inhibitors could be used to alleviate the symptomsof cholinergic dysfunction and improve cognitive functions in patientssuffering from AD.