Alzheimer’s disease (AD) is a neurodegenerativebrain disease. As the population continuesto age, the number of AD patients isexpected to rise and is anticipated to reach 150 million by 2050. AD is defined by β-amyloid (Aβ)-containingextracellular plaques, tau-containing intracellular neurofibrillarytangles, oxidative stress and cholinergic dysfunction. These pathologies reduce the levels of the neurotransmitteracetylcholine (ACh)­in the brain, leading to cognitive disabilities,learning deficits and severe memory impairment in patients.−, This evidence concerns the gene MAPT and Alzheimer disease.