PTTG1 and metastatic malignant neoplasm in the lymph nodes: At the mRNA level, PTTG1 is more present in patients with high histologic grade and with lymph node metastasis, is significantly associated with low patient survival, and is a biomarker suggestive of poor prognosis in breast cancer, which may be related to the regulation of the cell cycle by PTTG1 to promote the development of breast cancer cells (Meng et al., 2020).