MYH4 and cancer: We enrolled MYH4 for further validation based on the following reasons: (a) the MYH4 gene is situated on chromosome 17p, a region commonly lost in multiple cancer types (27, 28); (b) the role of MYH4 in genome maintenance and tumorigenesis is not yet explored; and (c) we speculated that noncanonical functions of MYH4 might operate in DNA repair and replication given the newly discovered relevance of actin and myosin in this context (8, 9, 29–32).