PBRM1 and neoplasm: First, we demonstrated that pancreatic Pbrm1 deletion resulted in the accelerated formation of poorly differentiated PDAC, concomitant with increased metastasis and worse prognosis in mice with activated Kras and heterozygous or homozygous disruption of Trp53, which established that PBRM1 plays tumor-suppressive roles in PDAC formation and progression.