These results are in keeping with PROX1’s role in normal neural development as a driver of early neural progenitor cells (13–18) and recent work demonstrating that PROX1 plays a role in regulating lineage plasticity and a fetal progenitor state in colorectal cancer (41), and they suggest that PROX1 induction may facilitate a cell state that is more conducive to or tolerant of differentiation change to terminal states such as progenitor-like DNPC or NEPC. Here, PROX1 is linked to colorectal cancer.