Furthermore, by examining scRNA-Seq data, we determined that PROX1 is upregulated in a progenitor-like DNPC population marked by high expression of the transcription factor SOX2 — a Yamanaka reprogramming factor (38) that is implicated in prostate cancer lineage plasticity (39, 40) — but not in a KRT7-positive DNPC cell population. Here, PROX1 is linked to Familial prostate cancer.