In agreement with our bioinformatics analyses and our experimental validation of CNPY3 APA in cell models of TDP-43 depletion, we observed significant CNPY3 APA, corresponding with increased expression of CNPY3 isoform variant 2 in the frontal cortex of TDP-43 proteinopathy patients (Figure 3E). Here, CNPY3 is linked to proteostasis deficiencies.