Two independent reports have also evaluated the effect of TDP-43 depletion in postmortem ALS/FTD patient neuron nuclei using an identical transcriptome data set (27), and despite employing distinct APA detection algorithms and bioinformatics analysis pipelines, both investigations identified hundreds of TDP-43 target genes subject to APA (40, 41), underscoring the relevance of TDP-43 dysregulation of poly(A) site selection to the disease process in TDP-43 proteinopathy. Here, TARDBP is linked to proteostasis deficiencies.