To further determine the significance of TDP-43 APA dysregulation in human patients, we considered APA events in neuron nuclei obtained from 7 postmortem ALS/FTD neocortex samples, where FACS sorting resulted in transcriptome data sets for neurons either containing or depleted of nuclear TDP-43 (27). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.