Although TRPM3 is a non-selective cation permeable channel, mutations in this gene have not yet been reported to cause effects on calcium homeostasis or metabolism.7 Furthermore, two missense mutations in TRPM3 have been associated with neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.7 A well-characterized function of TRPM3 in the literature pertains to its role in thermal nociception.8 This report represents the first instance of a TRPM3 mutation impacting calcium channel function. This evidence concerns the gene TRPM3 and neurodevelopmental disorder.