TRPM3 and Intellectual disability: Although the pathophysiological effects of TRPM3 mutations in humans remain largely unexplored, recent research has identified two missense mutations in TRPM3 that are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.7 A well-characterized function of TRPM3 in the literature pertains to its role in thermal nociception.8 However, the effects of these mutations on the functionality of calcium channels have yet to be investigated.