The most common mutations were TP53 (37%), ASXL1 (22%), and DNMT3A (18%) in MDS and ASXL1 (61%), TET2 (61%), NRAS (28%), and SRSF2 (22%) in CMML (supplemental Figures 1-3). The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.