Antiglycan antibodies in human serum play an integral role in humanimmune defense, homeostasis, and autoimmunity. Antibody profiling in healthy subjects provides fundamentalinformation about the immune system and enhances our insights intohow the immune system responds to infection, disease onset and progression,vaccination, and managing treatments. While prior studies have profiled IgG and IgM responses in serum,there is a lack of studies reporting on titers of IgG, IgM, and IgAantiglycan antibodies in individual human serum samples. The gene discussed is CD40LG; the disease is infection.