According to the research results of cell type-specific regulatory activity, the most activated TFs in these myeloma cell subgroups included ETV7(C0 GNB2L1+ NK cells), TAF1(C1 RACK1+ NK cells), POU2F2(C2 HNRNPH1+ NK cells), and RUNX2(C3 ATP5E+ NK cells) (Figure 7(a)). This evidence concerns the gene RUNX2 and plasma cell myeloma.