BRCA1 and BRCA2 are the most common pathogenic variants associated with hereditary breast and ovarian cancer syndrome.12 However, our case highlights the importance of completing multi-gene panel testing to identify non-BRCA genes that are associated with hereditary BC to facilitate precision medicine and risk-reduction strategies.14 Our case had a PTEN (Phosphatase and Tensin Homologue) pathogenic variant. This evidence concerns the gene PTEN and breast cancer.