For instance, The transplantation of MSCs activates the host nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, resulting in the inhibition of ferroptosis and a subsequent reduction in severe acute pancreatitis-associated acute lung injury (SAP-ALI) [105]; The up-regulation of Linc00616 in PDLSCs following periodontitis and Porphyromonas gingivalis lipopolysaccharide (LPS-PG) treatment has been observed. This evidence concerns the gene NFE2L2 and periodontitis.